I have a solution with 36 projects.
When I’m working on one of the projects I’d like to be able to debug it without having to right click the project then select ‘debug’ then select ‘start new instance’.
Practice As Follows
You could add in the Options dialog under Environment->Keyboard
"ClassViewContextMenus.ClassViewProject.Debug.Startnewinstance" as a shortcut.
This starts debugging on the current project.
(maybe this changed a bit for 2010)